The DNA foundry

Build without limits

Build your most ambitious designs without traditional limits to complexity with plasmid synthesis up to 50 kbp.

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The Challenge

The DNA bottleneck

DNA synthesis and assembly is for many, the most frustrating bottleneck in research and development programs. Assembly strategies consume time, success can be unpredictable and complexity can hold up your whole development program.

DNA synthesis & assembly

Free your team to focus on what counts
Get straight to research and leave us to build your DNA constructs for you. Save the time and headache of in-house assemblies so you can free your team to focus on the work that counts.
Plasmid Synthesis
Your plasmids arrive comprehensively optimised for your application of choice. Our Neural Network assembly algorithm is able to solve real world assembly problems with over 93% accuracy for even complex sequences. It means we can tackle even the toughest synthesis challenges and provide a quality, optimised plasmid from 20 days.
  • Assemblies of plasmids up to 50kb.
  • >80% and <20% GC content.
  • Complexity tackled as standard.
  • from €0.19 per bp.
Library Synthesis
Build libraries of samples up to 10^9 variants, NGS quality checked and with industry leading bias controls to ensure balanced representation of your target sequences.
  • Synthetic library depth to 10^9.
  • NGS sequencing and bias controls.
  • Complexity as standard.
Quality Control
All constructs are 100% sequenced verified with Sanger sequencing or NGS where necessary. Constructs and synthetic libraries are produced to our rigorous laboratory procedures according ISO 9001:2008 standards.
  • Troubleshooting as standard.
  • Scarless assembly and optional codon optimisation.
  • ISO 9001:2008 laboratory standards.
  • Sequence perfect guarantee.
Delivery
Standard turnaround time (TAT) for our plasmid assembly services starts from 20 days. Of course, depending on complexity TAT may vary accordingly. Average turnaround is currently 21 days. We’ll estimate delivery during checkout and keep you up to date in real-time.
  • Turnaround starting from 20 working days.
  • Real-time project updates and one-to-one support.
  • Lyophilized DNA options in a range of prep sizes
    (1 ug, 10 ug, 50 ug, 5 mg).
  • E. coli stab agar and glycerol stock delivery options.
  • Simple online ordering.
Your plasmids arrive comprehensively optimised for your application of choice. Our Neural Network assembly algorithm is able to solve real world assembly problems with over 93% accuracy for even complex sequences. It means we can tackle even the toughest synthesis challenges and provide a quality, optimised plasmid from 20 days.
  • Assemblies of plasmids up to 50kb.
  • >80% and <20% GC content.
  • Complexity tackled as standard.
  • from €0.19 per bp.
Build libraries of samples up to 10^9 variants, NGS quality checked and with industry leading bias controls to ensure balanced representation of your target sequences.
  • Synthetic library depth to 10^9.
  • NGS sequencing and bias controls.
  • Complexity as standard.
All constructs are 100% sequenced verified with Sanger sequencing or NGS where necessary. Constructs and synthetic libraries are produced to our rigorous laboratory procedures according ISO 9001:2008 standards.
  • Troubleshooting as standard.
  • Scarless assembly and optional codon optimisation.
  • ISO 9001:2008 laboratory standards.
  • Sequence perfect guarantee.
Standard turnaround time (TAT) for our plasmid assembly services starts from 16 days. Of course, depending on complexity TAT may vary accordingly. Average turnaround is currently 21 days. We’ll estimate delivery during checkout and keep you up to date in real-time.
  • Turnaround starting from 20 working days.
  • Real-time project updates and one-to-one support.
  • Lyophilized DNA options in a range of prep sizes
    (1 ug, 10 ug, 50 ug, 5 mg).
  • E. coli stab agar and glycerol stock delivery options.
  • Simple online ordering.
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>80%<20%
GC content

Complexity made simple

For most vendors, complex sequences such as secondary structure, repeats, high GC content or polypurine/polypyrimidine runs are impossible. Not with Officinae Bio, our sophisticated assembly methods and proprietary tech means we are able to tackle even the most complex projects.
100%
sequence perfect guarantee

Quality as standard

All plasmids are rigorously quality controlled. Every plasmid is 100% Sanger sequence verified meaning you certain of the quality your sample.
93%
succesful delivery in 2021

Industry leading successs

Build more without the limits of DIY assemblies and unreliable outsourcing. With a greater than 93% success rate in 2021 you can finally perform those experiments you thought impossible.
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Case Studies

AI-designed assembly of intractable constructs

35% reduced time to prototype
Business challenge

A developer of bio-based Antibiotics, designed a 35 kbp metabolic pathways for the biosynthesis of an antibiotic for the treatment of juvenile acne containing  enzymes from the Streptomyces genus with an avg. GC content > 72% preventing the synthesis of the constructs.

Solution Delivered

OB deployed its proprietary AI-driven algorithm to design DNA fragments that could be both synthesized and assembled using the client’s assembly method of choice (Gibson assembly).

Impact created

OB delivered Sanger-verified clones in 6 months vs. 9+ months it took the client to achieve the same results. Protocols were transferred to the client for subsequent assemblies increasing the first-try success rate.

You do the discovery,
we do the DNA.

Increase research output without ever touching a piece of DNA. Simply order online and we’ll handle the rest. With all that time saved, you're free to spend more of it on discovery.

World class support when you need it

Throughout your project you get personal, expert support in planning, ordering and troubleshooting your DNA. We talk strategy, help you discover parts, tackle assembly issues and solve expression hickups.

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